| Solution Information | help | |
| Enzyme: | Signal transducer and activator of transcription 3 [702-738,740-752] | |
| inhibitor: | BDBM37177 | |
| substrate: | n/a | |
| Solution Type: | Aqueous | |
| pH at Preparation: | n/a | |
| Temp. Prep.: | n/a | |
| Comments: | Assay Overview: The purpose of this assay is to determine dose response curves for compounds identified as active in a previous set of experiments entitled, "Primary cell-based high throughput screening assay to measure STAT3 inhibition" (PubChem AID 862), and that confirmed activity in a set of experiments entitled, "Confirmation cell-based high throughput screening assay to measure STAT3 inhibition" (AID 1265). The compounds selected for testing in this AID met the following criteria: 1) they were declared active in AID 862 and AID 1265; 2) they were declared inactive in a set of experiments entitled, "Primary cell-based high throughput screening assay to measure STAT1 inhibition" (AID 920); 3) they were inactive in a set of experiments entitled, "Counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure NF-kappaB inhibition" (AID 1308); and 4) they were inactive in a set of experiments entitled, "Counterscreen assay for STAT3 inhibitors: cell-based hi | |
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